Divalproex (Depakote, Depakote ER) can help with seizure control in certain types of epilepsy. This drug is used for other conditions, such as the treatment of bipolar disorder, mania, the prevention of migraines, and control of behavioral problems associated with dementia. Divalproex sodium delayed-release tablets or extended-release tablets by mouth. Do not crush or chew. If divalproex sodium upsets your stomach, take it with food or milk; do not take with carbonated drinks. Do not change brands or dosage forms of divalproex without discussing the change with your prescriber or healthcare professional.