Lamictal (lamotrigine) is prescribed to control seizures in people with epilepsy. It is also used to control a serious form of epilepsy known as Lennox-Gastaut syndrome. Lamictal is used in combination with other antiepileptic medications or as a replacement for a medication such as carbamazepine, phenytoin, phenobarbital, primidone, or valproate. Lamictal is used to help prevent the manic and/or depressive phases of bipolar disorder. You may develop a rash during the first 2 to 8 weeks of Lamictal therapy, particularly if you are also taking Depakene or Depakote. If this happens, notify your doctor immediately. The rash could become severe and even dangerous, particularly in children. Signs of a more serious reaction include hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, or swelling of the lips or tongue. A slight possibility of this problem remains for up to 6 months.