Zoloft (Sertraline) is used to treat depression, panic attacks, obsessive compulsive disorders (OCD), and post-traumatic stress disorder (PTSD). This medication works by helping to restore the balance of certain natural chemicals in the brain. This medication has also been used to treat a severe form of premenstrual syndrome (premenstrual dysphoric disorder- PMDD) and a sexual function problem in men (premature ejaculation).