Ezetrol (Zetia, Ezetimibe) is unique in the way it helps block the absorption of cholesterol that comes from food. Statins work mainly with the liver. Ezetimibe reduces the amount of cholesterol absorbed by the body. Ezetimibe is used to reduce the amount of total cholesterol, LDL, and a protein needed to make cholesterol in the blood. Ezetimibe is used with statins and fenofibrates. side effects while taking Ezetimibe, including tiredness, stomach pain, muscle pain or weakness.