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Immunosuppressants are a general class of medications that suppress the immune system. They are often used against diseases of the immune system and are also used to prevent transplant in organ transplants. Immunosuppressants versus antihistamines are not a type of antihistamine. Antihistamines are used to respond to an acute attack or over-response by the immune system. Immunosuppressants are usually longer-lasting drugs and work in a different manner, usually by interfering with the body's white blood cells (T-cells or B-cells). Immunosuppressants are often used to treat inflammatory and autoimmune diseases, such as inflammatory bowel disease, and to prevent organ or tissue rejection after a transplant. Immunosuppressant medications, which are also known as immunosuppressive medications, are a group of drugs that suppress or slow down the immune system. Immunosuppressant drugs are used to prevent the body from rejecting transplanted organs or tissues and to slow down the immune response in people with certain autoimmune disorders. In the treatment of autoimmune disorders, Immunosuppressants are often used in combination with corticosteroids as corticosteroid-sparing agents in an effort to reduce the dose of corticosteroids and minimize side effects associated with high dose corticosteroids. Blood tests are used to evaluate any blood cell disorders or biochemical changes, for instance in liver or kidney function that may occur as a result of immunosuppressant medications. Side effects related to Immunosuppressants include high blood pressure, kidney problems, liver problems, and susceptibility to infection. Signs of infection, such as fever, chills, and lower back pain should be reported immediately.