Fosamax (Alendronate) reduces calcium loss from bones. It helps prevent bone loss and increases production of normal healthy bone in patients with Paget's disease, osteoporosis in females after menopause or patient use long-term of corticosteroids in men or women. This medicine should be taken in the morning on an empty stomach. patient should stay upright and drink one full glass of water to prevent any esophageal problems or acid-reflux.