Prempro (Premplus, Conjugated Estrogen/Medroxyprogestrone) tablets are a mixture of estrogen hormones combined with a progestin hormone. Estrogens are essential for maintaining normal female functions. Conjugated estrogens can help relieve symptoms of the menopause (hot flashes, night sweats, mood changes, and vaginal dryness and irritation), and also help to prevent the onset of osteoporosis. Medroxyprogesterone (a progestin) is helpful in reducing overgrowth of the lining of the uterus (the endometrium), which may help reduce your risk of endometrial cancer.